KMID : 1161420100130030615
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Journal of Medicinal Food 2010 Volume.13 No. 3 p.615 ~ p.620
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Effects of Short-Term Consumption of Bread Obtained by an Old Italian Grain Variety on Lipid, Inflammatory, and Hemorheological Variables: An Intervention Study
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Sofi Francesco
Ghiselli Lisetta Cesari Francesca Gori Anna Maria Mannini Lucia Casini Alessandro Vazzana Concetta Vecchio Vincenzo Gensini Gian Franco Abbate Rosanna Benedettelli Stefano
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Abstract
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The aim of this study was to evaluate the influence of short-term dietary intake of bread obtained by a selected variety of old grain grown in Tuscany, Italy on some parameters related to the atherosclerotic process. Twenty healthy subjects (median age, 39.5 years) followed for 10 weeks a diet containing bread (150?g/day) made from the test grain (test period) and for the same period a diet containing commercially available bread of the same quantity (control period). Lipid, inflammatory, and hemorheological profiles before and after dietary intervention were evaluated. The test period showed a significant (P?.05) improvement of total cholesterol (pre-intervention, 211.2?¡¾?10.8?mg/dL; post-intervention, 196.5?¡¾?9.8?mg/dL) and low-density lipoprotein-cholesterol levels (pre-intervention, 137.5?¡¾?8.1?mg/dL; post-intervention, 119.5?¡¾?7.5?mg/dL), whereas no significant changes during the control period were observed. With regard to inflammatory and hemorheological parameters, the test period showed a significant decrease in some of the parameters investigated (interleukin-8 [pre-intervention vs. post-intervention, 67.4?¡¾?10.7 vs. 43.9?¡¾?4.1?pg/mL], whole blood viscosity at high [4.36?¡¾?0.03 vs. 4.32?¡¾?0.03?mPa?¡¤?s, respectively] and low [26.1?¡¾?0.4 vs. 24.8?¡¾?0.5?mPa?¡¤?s, respectively] shear rates, and erythrocyte filtration [8.4?¡¾?0.7% vs. 9.1?¡¾?0.6%, respectively]) relative to the control period, which showed no significant changes. Short-term dietary intake of whole grain bread obtained from an old grain variety seems to impose a favorable status with regard to lower circulating levels of markers of atherosclerosis.
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KEYWORD
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bread, carbohydrates, cardiovascular diseases, grains
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